Category: Tech / Science

Spinal fluid washing over the brain during sleep to remove waste


See also:
Scientists Now Know How Sleep Cleans Toxins From the Brain
The synchronized brain waves of non-REM sleep may play a key role in preventing toxins from accumulating in a person’s brain.

One big contribution of the paper is it helps show that the systems Nedergaard has been studying in mice are present and hugely important for humans too. “It’s telling you sleep is not just to relax,” says Nedergaard. “Sleep is actually a very distinct function.” Neurons don’t all turn off at the same time when we’re awake. So brain blood levels don’t drop enough to allow substantial waves of cerebrospinal fluid to circulate around the brain and clear out all the metabolic byproducts that accumulate, like beta amyloid.

Sara Harrison
Wired

Tech Bros – Example Of

(Rap) Genius was one of the most unlikable tech startups of the past decade-plus. On a purely aesthetic level, its founders dressed like this and wore sunglasses indoors. They were non-Black people making money off of an overwhelmingly Black art form. They went from Yale and Stanford to working at hedge funds and law firms to deciding their new corporate image should be “we’re not afraid to tell Warren Buffett to suck a dick.” They said their site wasn’t “just crowdsourced…it was homiesourced…then we decided we wanted it to be ballersourced.” One of them got fired for writing that the manifesto left behind by incel spree murderer Elliot Rodger was “beautifully written” and that he guessed that Rodger’s sister was “smokin hot.”

True Genius: How to go from “the future of journalism” to a fire sale in a few short years
Genius (née Rap Genius) wanted to “annotate the world” and give your content a giant comment section you can’t control. Now it can’t pay back its investors.
JOSHUA BENTON

Distributed Online Research, Example of – Reddit, What is this?


What is this court? It doesn’t have basketball hoops and appears too long and skinny for anything I can think of. Also, it’s almost as long as 2 residential lots as seen in the picture. from whatisthisthing

Iraff2
I’ve researched the hell out of this thing, at this point I’m convinced it was a custom job designed for either a high-level athlete to practice a very specific thing or possibly some homebrewed sport invented by the owner. I can’t find ANY sport for which this might be a regulation court.

EDIT: Ok wait, just saw that there’s apparently another exact replica found in some city park in 2020. Maybe some landscaping company mocked this up as a General Use court you could just pluck off the shelf??? I bet some Toledo-based rink installers just whipped it up.

Susan_of_Darmuthia
I’ve also been researching a ton, I even went onto Google maps, figuring out that there’s a playground sign on either side of it. I read a listing for the house next door to it on a realtor website and that didn’t mention anything either. I can’t find anything online for playgrounds or parks on cribb street ohio. It’s also surrounded by a fence and pretty overgrown, it that helps at all. Edit: I research about the apartments next door to it, Riviera Maia, still nothing in all the listings or reviews. I’m officially giving up now, here’s my white flag 🏳 Good luck.

trebskate
Based on historic aerial photos, It was originally built between 1955 and 1963, as two singles only tennis courts, end to end. The width of the singles court is 27′ which matches exactly. You can clearly see the playing area and the serving areas as different colors and another fence in the middle. It existed like this until sometime between 1985 and 1999. By 1999 the court surface was (probably cheaply) resurfaced and they just threw on the bastardized hockey layout.

https://www.historicaerials.com/location/41.70404242075055/-83.57109099626543/map/18

Flatulent Rudy Guiliani – Fart, Farting Problem

Rudy Giuliani came once, but no one wanted him back. His phone rang constantly, and he couldn’t shut it off. He shuffled endless pieces of paper without being able to find what he was looking for. He couldn’t work his iPad to bring up what he wanted to show, reliably stalling meetings. And he went down rabbit holes—they could get Hunter Biden, if they could just find the guy who signed the forms to get Hunter the waiver to get into the military. And he passed gas, constantly.

The room had not been cleaned since Election Day, eleven days before. Refuse filled the trash cans and overflowed onto the floor. There was a heavy sour or rotting smell—in the trash was a week-old Buffalo chicken sandwich—mixed with Giuliani’s reliable farting.

Everyone sheepishly held to the president’s preference that the virus be mostly unacknowledged, masks eschewed and superspreader events overlooked, but there was, nevertheless, even without a formal tracking program in the White House, a reflex to blame each infection on someone, as the president had continued, at the least opportunity, to blame his own case of it on Chris Christie.

Now, in fact, the president was worried that the press was going to leave the impression that Giuliani had gotten the virus from him. “They blame me for everybody getting it,” he pronounced, looking for sympathy.

Then Jenna Ellis got it two days later (the West Wing joke being that she got it from a Giuliani fart).

Landslide: The Final Days of the Trump Presidency
Wolff, Michael

GitHub’s Engineering Team has moved to Retro Encabulators


GitHub’s Engineering Team has moved to Codespaces from programming

Full-Spectral
One day I’ll actually have heard of something that someone posts about… Seems like half the posts around here are whether I should use Ruby on Rufies in conjunction with Phlegm if I’m going to be using Scabby Framework over Psycho Units in order to maximize my leverage of the Mumble Cloud Bifurcated Distribution Network layer for hyper-scaling Uncontainers.

notsooriginal
Hey we’re looking for a forward thinking keynote speaker for our upcoming DevContainerCon, are you interested?

Sketches_Stuff_Maybe
Sorry, all my speeches are in Paragraph based Micro-Services, so you’re going to need to buy the extended SaaS subscription to have me speak about forward-facing backward synergetic conventions

See also:

Unnderrated Statistical Methods


[D] What is in your opinion an underrated Statistical method that should be used more often? from statistics

oose_rajamaeki
Plotting the data and inspecting it visually. Should be done every time if possible before doing any analyses.

Wu_Fan
Yeah fam. Visualise it. Not visualising is like a doctor who doesn’t read your notes.

HoosierTrip
LCA, LPA, and LTA are all underutilized. I think the perception is that they’re no different than cluster analysis, so why not use the easier method (like k means cluster analysis). I’ve seen so many people conflate IRT and CFA with them as well. I think a general lack of understanding about the approach is definitely a contributing factor.

IllmaticGOAT
Thinking about and modeling the generative process of your data.

Lewba
coarsened exact matching for causal inference.

Alkanste
Came to see this

Depression and Summer

Often, when Dr. Rosenthal talked about his research, someone would approach him to say that the same thing happened to them — but in the summer. In 1987, he and his colleagues published a report of 12 people who experienced a pattern of seasonal depression between March and October. This and subsequent work suggested that summer SAD presented differently than its winter counterpart, and might have different causes.

“Summer SAD is more of an agitated depression,” said Dr. Rosenthal, a clinical professor of psychiatry at the Georgetown University School of Medicine. While those with winter SAD tend to oversleep and overeat, summer SAD often shows up with insomnia and lowered appetite.

Seasonal Affective Disorder Isn’t Just for Winter
Feeling blue even though everyone seems to be basking in perfect summer weather? There might be a good reason for that.
Cameron Walker
NYTIMES

Overuse of Inheritance – Object Oriented Programming

Many of these books claim that by creating these abstractions, in this example Person, you can “re-use” them in other projects. However, in 15 years of my professional experience, I have hardly seen many (or any) examples of such abstractions being used across projects in a useful manner.

At one point, I started creating a class library of these abstractions that I could share across projects. After a little while, that class library ended up being bloated with lots of unrelated abstractions and versioning it across different projects ended up being a nightmare. If you have done this before, you may relate to this story.

Once I was engaged as a consultant for a greenfield project, and in the introductory session, the data architect of the project walked me through tons of UML class diagrams (more than 50 pages). Every class was inheriting from another class and eventually, they all led to a class that was called “Thing”! No joke!

What text books tell you about inheritance in OOP is wrong
Mosh Hamedani

AIDS – Early Warning of, New York Times – July 3, 1981

Doctors in New York and California have diagnosed among homosexual men 41 cases of a rare and often rapidly fatal form of cancer. Eight of the victims died less than 24 months after the diagnosis was made.

The cause of the outbreak is unknown, and there is as yet no evidence of contagion. But the doctors who have made the diagnoses, mostly in New York City and the San Francisco Bay area, are alerting other physicians who treat large numbers of homosexual men to the problem in an effort to help identify more cases and to reduce the delay in offering chemotherapy treatment.

The sudden appearance of the cancer, called Kaposi’s Sarcoma, has prompted a medical investigation that experts say could have as much scientific as public health importance because of what it may teach about determining the causes of more common types of cancer.

RARE CANCER SEEN IN 41 HOMOSEXUALS
Lawrence K. Altman
July 3, 1981