The song has been heavily sampled by many artists. Hip hop group De La Soul sampled the intro to the song in their hit “Me Myself and I“, which reached #34 on the Billboard Pop Charts and #1 on the R&B Charts.
Also LL Cool J (“Nitro”), Everlast (“Never Missin A Beat”), Tone Lōc (“Funky Cold Medina“), MC Hammer & Deion Sanders (“Straight to My Feet”), The rap group Mass 187 (“Swang Your Hips)”, G-Funk Intro & his unreleased track “Do U Remember”. Tha Dogg Pound used the sample in their unreleased track “Can’t C Us”. Geto Boys sampled the intro for “Homie Don’t Play That”. The Black Eyed Peas also used the beat behind it to remix their hit single “Shut Up“. X Clan sampled the song in “Funkin’ Lesson”. It was also interpolated in the song “Get Away” by Bobby Brown. In 2014, it was sampled in Jessie J‘s “Seal Me with a Kiss”.
Rapper Tupac Shakur sampled the song for his “Intro/Bomb First (My Second Reply)” and his Dr. Dre produced track “Can’t C Me”.
Dr. Dre’s song, “Fuck wit Dre Day (And Everybody’s Celebratin’)“, is based on “Knee Deep”.