The Butlerian Jihad a.k.a. The Great Revolt — two generations of chaos (200 BG – 108 BG). The god of machine-logic was overthrown by the masses and a new concept was raised:
“Man may not be replaced.”
After two generations of violence, humanity took pause. Following this, their gods and rituals were looked upon in a different, perhaps even jaded, light. Both were largely seen to be guilty of using fear as a means of control.
Hesitantly, the leaders of religions whose followers had spilled the blood of billions began meeting to exchange views. It was a move encouraged by the Spacing Guild, which was beginning to build its monopoly over all interstellar travel, and by the Bene Gesserit who were organizing their ranks.
By 108 BG, the Jihad itself had finished with the complete destruction of all intelligent machines that were originally built by humans throughout the worlds, but it proved to have many profound impacts on the socio-political and technological development of humanity throughout the new empires that emerged, including a large technological reversal of the entire human civilization.
The most dramatic long-lasting result was the ensuing commandment from the Orange Catholic Bible held sway to humans against the creation of machines which bore the human mind’s exact image: Thou shalt not make a machine in the likeness of a human mind, after the destruction of the man-made intelligent machines throughout the human worlds. Even the simplest computers and calculators were banned, with the penalty for building or owning such a thinking machine technology being put to trial and sentenced to immediate death.